The 'human eyes' effects by Weta are the most off-putting thing about 'Rise of the Planet of the Apes'. They have an insidious look, even in the shot below, where the chimp is emoting love and concern for the man.
Couldn't watch this at the theater. Thirty-foot tall ape faces aping those awful fake/weird looking humanoid eyes at me for two hours would be too much. (Thank god this isn't in 3D. People would run.)